发明名称 |
Flt3-L mutants and methods of use |
摘要 |
A screening method for identifying mutant polypeptides having at least one amino acid difference from a wild type protein involved in a receptor-ligand interaction is disclosed. Also disclosed are mutant polypeptides of the hematopoietic growth factor flt3-Ligand (flt3-L) identified using this method, nucleic acids encoding these flt3-L mutant polypeptides, and methods of treatment involving in vitro and in vivo use of the mutant polypeptides and nucleic acids.
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申请公布号 |
US2002111475(A1) |
申请公布日期 |
2002.08.15 |
申请号 |
US20010904536 |
申请日期 |
2001.07.16 |
申请人 |
IMMUNEX CORPORATION |
发明人 |
GRADDIS THOMAS J.;MCGREW JEFFREY T. |
分类号 |
A61K38/00;A61K39/39;C07K14/52;C12N5/0784;C12N15/10;C12N15/19;(IPC1-7):C07K14/475;C07H21/04;C12P21/02;C12N5/06 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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