NATRIURETIC PEPTIDES AND PLACENTAL-GROWTH FACTOR/SOLUBLE VEGF-RECEPTOR DISCRIMINATE CARDIAC DYSFUNCTION RELATED TO HEART DISEASE FROM A PLACENTA-ASSOCIATED CARDIAC DYSFUNCTION IN PREGNANT WOMEN

摘要

The present invention relates to a method for diagnosing if a pregnant woman suffers from a cardiac dysfunction, comprising the steps of a) measuri ng the level of a Natriuretic peptide in a sample b) measuring the level of Placent al- growth Factor and/or sFlt-1 or a variant thereof in a sample wherein an increased level of a Natriuretic peptide and a decreased level of Placental-growth Factor and/ or an increased level of sFlt-1 or a variant thereof indicates the presence of a placenta--associated cardiac dysfunction, or wherein an increased level of a Natriuretic peptide and a not decreased level of Placental-growth Factor and/ or a not increased level of sFlt-1 or a variant thereof indicates the presence of a cardiac dysfunction related to heart disease. The present invention also relates to an array, to an immunological rapid test, to the use of corresponding kits and to methods of for a decisio n support for the possible treatment of a pregnant woman suffering from a cardiac dysfunction.