COMPOSITIONS AND METHODS USING CAPSIDS RESISTANT TO HYDROLASES

摘要

Novel processes and compositions are described which use viral capsid proteins resistant to hydrolases to prepare virus-like particles to enclose and subsequently isolate and purify target cargo molecules of interest including nucleic acids such as siRNAs and shRNAs, miRNAs, messenger RNAs, small peptides and bioactive molecules.

主权项

1. A virus-like particle (VLP) comprising a protease resistant capsid enclosing at least one heterologous cargo molecule, the cargo molecule further comprising a capsid specific packing sequence.