Anti-ETBR antibodies and immunoconjugates

摘要

The invention provides anti-ETBR antibodies and immunoconjugates and methods of using the same. In some embodiments, an immunoconjugate comprising an antibody that binds ETBR covalently attached to a cytotoxic agent is provided, wherein the antibody binds an epitope within amino acids 64 to 101 of SEQ ID NO: 10. In some embodiments, the cytotoxic agent is a pyrrolobenzodiazepine.

主权项

1. A method of treating an individual having an ETBR-positive cancer, wherein the ETBR-positive cancer is resistant to a first immunoconjugate comprising a first antibody that binds ETBR and a first cytotoxic agent which is an auristatin, the method comprising administering to the individual an effective amount of an immunoconjugate comprising an antibody that binds ETBR covalently attached to a cytotoxic agent, wherein the antibody binds an epitope within amino acids 64 to 101 of SEQ ID NO: 10, and wherein the cytotoxic agent is a pyrrolobenzodiazepine.