| 发明名称 |
P2X7 modulators |
| 摘要 |
The present invention is directed to compounds of Formulas (I, IIa and IIb):;
The invention also relates to pharmaceutical compositions comprising compounds of Formulas (I, IIa and IIb). Methods of making and using the compounds of Formulas (I, IIa and IIb) are also within the scope of the invention. |
| 申请公布号 |
US9464084(B2) |
申请公布日期 |
2016.10.11 |
| 申请号 |
US201514714714 |
申请日期 |
2015.05.18 |
| 申请人 |
Janssen Pharmaceutica NV |
发明人 |
Alcazar Vaca Manuel Jesus;Andres Gil Jose Ignacio;Chrovian Christa C.;Coate Heather R.;De Angelis Meri;Dvorak Curt A.;Gelin Christine F.;Letavic Michael A.;Savall Brad M.;Soyode-Johnson Akinola;Stenne Brice M.;Swanson Devin M. |
| 分类号 |
C07D471/04;A61K31/497;C07F7/08;C07D401/14 |
主分类号 |
C07D471/04 |
| 代理机构 |
|
代理人 |
Atkins Michael |
| 主权项 |
1. A compound that is: (R*)-(2-Chloro-3-(trifluoromethyl)phenyl)(1-(5-fluoropyrimidin-2-yl)-4-methyl-6,7-dihydro-1H-[1,2,3]triazolo[4,5-c]pyridin-5(4H)-yl)methanone; and pharmaceutically acceptable salts thereof. |
| 地址 |
BE |
