发明名称 |
Process of preparing 3-(3-(4-(1-aminocyclobutyl)phenyl)-5-phenyl-3H-imidazo[4,5-B]pyridin-2-yl)pyridin-2-amine |
摘要 |
The present invention is directed to a processes for the synthesis of 3-(3-(4-(1-aminocyclobutyl)phenyl)-5-phenyl-3H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-amine:; |
申请公布号 |
US9464083(B2) |
申请公布日期 |
2016.10.11 |
申请号 |
US201514666694 |
申请日期 |
2015.03.24 |
申请人 |
ArQule Inc. |
发明人 |
Bates Craig;Chen Jian-Xie;Mao Jianmin;Reed David P. |
分类号 |
C07D471/04;C07D213/74 |
主分类号 |
C07D471/04 |
代理机构 |
Cooley LLP |
代理人 |
Cooley LLP ;Elrifi Ivor R.;Pavao Matthew |
主权项 |
1. A process of preparing 3-(3-(4-(1-aminocyclobutyl)phenyl)-5-phenyl-3H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-amine, comprising the steps of
Step 3, reacting tert-butyl (1-(4-((3-amino-6-phenylpyridin-2-yl)amino)phenyl)cyclobutyl)carbamate with 2-amino nicotinaldehyde in the presence of an oxidant and an acid in a polar protic solvent to form tert-butyl (1-(4-(2-(2-aminopyridin-3-yl)-5-phenyl-3H-imidazo[4,5-b]pyridin-3-yl)phenyl)cyclobutyl)carbamate; and Step 4, treating tert-butyl (1-(4-(2-(2-aminopyridin-3-yl)-5-phenyl-3H-imidazo[4,5-b]pyridin-3-yl)phenyl)cyclobutyl)carbamate with an acid in a polar aprotic solvent to form 3-(3-(4-(1-aminocyclobutyl)phenyl)-5-phenyl-3H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-amine. |
地址 |
Burlington MA US |