| 发明名称 | Anti-malarial agents | ||
| 摘要 | The present invention is related to a use of pyrazole derivatives in the manufacture of a medicament for preventing or treating malaria. Specifically, the present invention is related to pyrazole derivatives useful for the preparation of a pharmaceutical formulation for the inhibition of malaria parasite proliferation. | ||
| 申请公布号 | US9464057(B2) | 申请公布日期 | 2016.10.11 |
| 申请号 | US201414905369 | 申请日期 | 2014.07.17 |
| 申请人 | MMV MEDICINES FOR MALARIA VENTURE;DREXEL UNIVERSITY;UNIVERSITY OF WASHINGTON | 发明人 | Burrows Jeremy;Wyvratt Matthew;Vaidya Akhil;Kortagere Sandhya;Fan Erkang;Chatterjee Arnab Kumar;Nagle Advait Suresh;Kato Tomoyo |
| 分类号 | C07D403/12;C07D231/40;A61K31/4184;A61K45/06;A61K31/415 | 主分类号 | C07D403/12 |
| 代理机构 | Saliwanchik, Lloyd & Eisenschenk | 代理人 | Saliwanchik, Lloyd & Eisenschenk |
| 主权项 | 1. A pyrazole derivative according to Formula (I), wherein X1 is selected from F and H; X2 is selected from Cl and F; R1 is selected from methyl and trifluoromethyl; R2 is selected from the following groups:as well as any pharmaceutically acceptable salt, hydrate, solvate, polymorph, tautomers, geometrical isomers, or optically active isomers thereof. | ||
| 地址 | Geneva CH | ||