发明名称 |
PTH FORMULATIONS AND METHODS OF USE |
摘要 |
What is described is an aqueous pharmaceutical formulation of PTH, comprising PTH(I -34) and a nonionic surface active agent, a dosage form comprising the formulation, a system of delivering PTH to a human, comprising exposing a layer of mucosal cells to the formulation, and a method of using such formulation for treating osteoporosis in a mammal, preferably wherein a time to maximum plasma concentration, Tmax, of PTH(I -34) following administration is less than 30 minutes. Also described is a method for treating osteoporosis in a mammal comprising administering intranasally a PTH formulation comprises a therapeutically effective amount of PTH(I -34) and one or more excipients selected from the group consisting of a solubilizing agent, a chelating agent, and one or more polyols. Comprising PTH(l-34) and a nonionic surface active agent. Also described is a use of PTH(l-34) in the manufacture of a medicament for treating osteoporosis in a mammal, wherein the medicament comprises a therapeutically effective amount of PTH(I -34) and one or more excipients selected from the group consisting of a nonionic surface active agent, a solubilizing agent, a chelating agent, and one or more polyols. |
申请公布号 |
WO2007044069(A2) |
申请公布日期 |
2007.04.19 |
申请号 |
WO2006US13377 |
申请日期 |
2006.04.10 |
申请人 |
NASTECH PHARMACEUTICAL COMPANY INC.;COSTANTINO, HENRY, R.;QUAY, STEVEN, C.;TEMPLIN, MICHAEL, V.;LI, CHING-YUAN;SILENO, ANTHONY |
发明人 |
COSTANTINO, HENRY, R.;QUAY, STEVEN, C.;TEMPLIN, MICHAEL, V.;LI, CHING-YUAN;SILENO, ANTHONY |
分类号 |
A61K38/29;A61K47/18;A61K47/24;A61K47/26;A61K47/40 |
主分类号 |
A61K38/29 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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