MUTANT CHANNELRHODOPSINS WITH ALTERED ION SELECTIVITY

摘要

The invention, in some aspects relates to compositions and methods for altering cell activity and function and the introduction and use of mutant light-activated ion channels and variants thereof.

主权项

1. A light-activated ion channel polypeptide comprising an amino acid sequence set forth as SEQ ID NO:1 comprising one or more amino acid modifications, or a variant thereof; wherein the one or more amino acid modifications comprise 1, 2, 3, 4, 5, 6, 7, or 8 A71S, I84L, I84V, E90A, E90D, E90N, E90P, E90Q, M91L, H114G, R115S, E123A, or K205A amino acid substitutions.