| 发明名称 |
7-AMINOCEPHEM DERIVATIVE COMPOUNDS |
| 摘要 |
This disclosure provides methods of making certain 7-aminocephem derivatives useful in the manufacture of cephalosporin antibiotic compounds. |
| 申请公布号 |
US2016176897(A1) |
申请公布日期 |
2016.06.23 |
| 申请号 |
US201514974223 |
申请日期 |
2015.12.18 |
| 申请人 |
MERCK SHARP & DOHME CORP. |
发明人 |
MOSHOS Kristos Adrian;JURKAUSKAS Valdas |
| 分类号 |
C07D501/04 |
主分类号 |
C07D501/04 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of making compound (II): comprising the steps of: (a) forming a reaction mixture comprising phosphorous pentachloride (PCl5) and pyridine; (b) adding compound (IIa) to the reaction mixture: (c) adding isobutyl alcohol; (d) adding a solvent comprising water; (e) adding ethyl acetate; and (f) obtaining compound (II). |
| 地址 |
Rahway NJ US |
