| 摘要 |
Inhibitors of HBV replication of Formula (IA);;including stereochemically isomeric forms, and salts, hydrates, solvates thereof, wherein X and R1 to R6 have the meaning as defined herein.;The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HBV inhibitors, in HBV therapy. |
| 主权项 |
1. A compound of Formula (IA)or a stereoisomer or tautomeric form thereof, wherein:
each X independently is CR7; R1, R2 and R3 are independently selected from the group consisting of hydrogen, fluoro, chloro, bromo, —CHF2, —CH2F, —CF3, —CN, C1-C3alkyl and C3-C4cycloalkyl; R4 is selected from the group consisting of hydrogen, C1-C3alkyl and C3-C4cycloalkyl; R5 is hydrogen; R6 is selected from the group consisting of C1-C6alkyl and a 3-7 membered saturated ring optionally containing one or more heteroatoms each independently selected from the group consisting of O, S and N, said C1-C6alkyl or said 3-7 membered saturated ring is optionally substituted with one or more substituents selected from the group consisting of fluoro, C3-C4cycloalkyl, —OR8, oxo, —CN, —C(═O)—OR8, —C(═O)—N(R8)2 and C1-C3alkyl, wherein said C1-C3alkyl is optionally substituted with one or more fluoro; each R7 is independently selected from the group consisting of hydrogen, C3-C4cycloalkyl, —CN, fluoro, chloro, bromo and C1-C3alkyl, wherein said C1-C3alkyl is optionally substituted with one or more fluoro; R8 is hydrogen or C1-C3alkyl;or a pharmaceutically acceptable salt or a solvate thereof. |
