发明名称 |
COMPOSITION AND METHOD FOR ENABLING PROLIFERATION OF PLURIPOTENT STEM CELLS |
摘要 |
The present disclosure is directed to the development of compositions, such as extracellular matrices, and processes for using the same, that both maintain stem cells in vitro pluripotency and enable self-renewal. In this regard, it has been discovered that when pluripotent mouse and human embryonic stem cells are cultured on plates coated with recombinant laminin-10 (laminin-511) or their functional domains, in the absence of differentiation inhibitors or feeder cells, the embryonic stem cells proliferated and maintained their pluripotency. |
申请公布号 |
EP3078739(A1) |
申请公布日期 |
2016.10.12 |
申请号 |
EP20160000633 |
申请日期 |
2010.08.24 |
申请人 |
DOMOGATSKAYA, ANNA;RODIN, SERGEY;TRYGGVASON, KARL |
发明人 |
DOMOGATSKAYA, ANNA;RODIN, SERGEY;TRYGGVASON, KARL |
分类号 |
C12N5/073;C12N5/0735 |
主分类号 |
C12N5/073 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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