| 摘要 |
PROBLEM TO BE SOLVED: To provide fusion proteins that form trimers, which proteins enable efficient production of recombinants provided with both good trimerization properties and improved pharmaceutical properties.SOLUTION: The invention provides a fusion protein comprising: (i) collectin family trimer-forming domain comprising a. a collectin family carbohydrate recognition domain and b. a collectin family neck region; (ii) a linker element; and (iii) an effector polypeptide, where the effector polypeptide is located at the N-terminus of the collectin family neck region. As described herein, the fusion proteins and nucleic acids encoding the same are suitable as pharmaceutical compositions or for therapeutic, diagnostic and/or research applications.SELECTED DRAWING: None |
