发明名称 |
HIV-1 MUTATIONS SELECTED FOR BY &bgr;-2',3'-DIDEHYDRO-2',3'-DIDEOXY-5-FLUOROCYTIDINE |
摘要 |
The present invention discloses a method for treating HIV that includes administering beta -D-D4FC or its pharmaceutically acceptable salt or prodrug to a human in need of therapy in combination or alternation with a drug that induces a mutation in HIV-1 at a location other than the 70(K to N), 90 or the 172 codons of the reverse transcriptase region. Also disclosed is a method for using beta -D-D4FC as "salvage therapy" to patients which exhibit drug resistance to other anti-HIV agents. beta -D-D4FC can be used generally as salvage therapy for any patient which exhibits resistance to a drug that induces a mutation at other than the 70(K to N), 90 or the 172 codons. |
申请公布号 |
PL198237(B1) |
申请公布日期 |
2008.06.30 |
申请号 |
PL20000349576 |
申请日期 |
2000.01.21 |
申请人 |
EMORY UNIVERSITY |
发明人 |
SCHINAZI RAYMOND F.;HAMMOND JENNIFER;MELLORS JOHN W.;LIOTTA DENNIS C. |
分类号 |
A61K31/513;C12N15/01;A61K31/70;A61K31/7068;A61K45/00;A61K45/06;A61P31/18 |
主分类号 |
A61K31/513 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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