发明名称 |
PSMA ANTIBODIES AND PROTEIN MULTIMERS |
摘要 |
The invention includes antibodies or antigen-binding fragments thereof which bind specifically to conformational epitopes on the extracellular domain of PSMA, compositions containing one or a combination of such antibodies or antibodies or antigen-binding fragments thereof, hybridoma cell lines that produce the antibodies, and methods of using the antibodies or antigen-binding fragments thereof for cancer diagnosis and treatment. The invention also includes oligomeric forms of PSMA proteins, compositions comprising the multimers, and antibodies that selectively bind to the multimers. |
申请公布号 |
CA2464239(C) |
申请公布日期 |
2016.07.12 |
申请号 |
CA20022464239 |
申请日期 |
2002.10.23 |
申请人 |
PSMA DEVELOPMENT COMPANY, L.L.C.;AMGEN FREMONT INC. |
发明人 |
MADDON, PAUL J.;DONOVAN, GERALD P.;OLSON, WILLIAM C.;SCHUELKE, NORBERT;GARDNER, JASON;MA, DANGSHE;KANG, JASPAL S.;GREEN, LARRY |
分类号 |
C12N15/13;G01N33/50;A61K31/7088;A61K38/00;A61K38/21;A61K39/395;A61K45/00;A61K47/48;A61K48/00;A61K49/00;A61K51/10;A61P31/12;A61P35/00;A61P37/02;A61P37/04;A61P43/00;C07K14/705;C07K16/28;C07K16/30;C07K16/46;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N5/12;C12N15/09;C12P21/08;C12Q1/02;C12Q1/34;C12Q1/37;G01N33/15;G01N33/53;G01N33/554;G01N33/574 |
主分类号 |
C12N15/13 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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