发明名称 SELECTED ANTIBODIES AND USE THEREOF IN TREATMENT
摘要 PROBLEM TO BE SOLVED: To provide novel methods and compositions for safe and effective tumor vessel targeting, anti-angiogenesis, and tumor destruction.SOLUTION: The invention discloses a surprising discovery involved in a role of anionic phospholipid and amino phospholipid in a tumor vascular structure and virus invasion and spread, as well as compositions and methods for use these findings in the treatment of cancer and viral infection. The invention also discloses advantageous antibodies, immunoconjugates, and duramycin based compositions and combinations, which bind to and inhibit anionic phospholipid and amino phospholipid, for use in safe and effective treatment of cancer, viral infection, and related diseases.SELECTED DRAWING: None
申请公布号 JP2016135819(A) 申请公布日期 2016.07.28
申请号 JP20160090246 申请日期 2016.04.28
申请人 BOARD OF REGENTS THE UNIV OF TEXAS SYSTEM 发明人 THORPE PHILIP E;SOARES MELINA M;HUANG XIANMING;HE JIN;RAN SOPHIA
分类号 A61K39/395;A61K45/00;A61K9/08;A61K9/12;A61K9/127;A61K9/14;A61K31/337;A61K47/10;A61P3/04;A61P3/10;A61P5/14;A61P7/04;A61P7/06;A61P9/00;A61P9/10;A61P15/08;A61P17/00;A61P17/06;A61P17/10;A61P19/02;A61P19/06;A61P27/02;A61P27/06;A61P29/00;A61P31/10;A61P31/12;A61P31/22;A61P33/00;A61P35/00;A61P37/02;A61P43/00;C07K16/18;C07K16/28;C07K16/44 主分类号 A61K39/395
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