Method for inducing differentiation enabling tumorigenesis of IPS cells to be suppressed

摘要

The object of the invention is to provide a technique of suppressing tumorigenesis in IPS cells and inducing differentiation into target differentiated cells. In use of a statin and a differentiation inducer, iPS cells are differentiated into target differentiated cells, whereby iPS cells can be differentiated into differentiated cells in which tumorigenesis is suppressed.

主权项

1. A method for inducing differentiation of iPS cells while suppressing tumorigenesis, the method comprising:
adding to the iPS cells a statin and a differentiation inducer, wherein the differentiation inducer is known to cause differentiation of the iPS cells into osteoblasts, and permitting differentiation of the iPS cells into osteoblasts, wherein the differentiation of the iPS cells is induced by the differentiation inducer, and wherein tumorigenesis is suppressed by the statin, wherein the statin is a compound represented by General formula (A) below: wherein the carboxyl group may form a ring structure with the hydroxyl group in the third position, and Ri represents any of the groups shown in General Formulas (1) and (2) below: wherein R1a and R1b may be the same or different, and are each hydrogen atoms or C1-5 linear or branched alkyl groups; and R1c and R1d may be the same or different, and are each hydrogen atoms, hydroxyl groups or C1-5 linear or branched alkyl groups; wherein R2a is a halogen-substituted phenyl group, and R2b is a C1-5 linear or branched alkyl group.