发明名称 |
POLYSACCHARIDES COMPRISING TWO ANTITHROMBIN III-BINDING SITES, PREPARATION THEREOF AND USE THEREOF AS ANTITHROMBOTIC MEDICAMENTS |
摘要 |
The invention relates to sulphated polysaccharides which have the general structure of the constituent polysaccharides of heparin and which have a molecular weight of less than 8000 Daltons, comprising two antithrombin III-binding hexasaccharide sequences corresponding to formula (I):;in which:R1 represents an OH group when the hexasaccharide of formula (I) is located at the reducing end of the polysaccharide, or else R1 represents a bond with another saccharide unit of said polysaccharide,R2 represents a hydrogen atom when the hexasaccharide of formula (I) is located at the non-reducing end of the polysaccharide, in which case the bond between carbon atoms 4 and 5 of the first saccharide unit of said hexasaccharide is a double bond, or else R2 represents a bond with another saccharide unit of said polysaccharide, in which case the bond between carbon atoms 4 and 5 of the first saccharide unit is a single bond.;Preparation thereof, use thereof as antithrombotic medicaments, and also use thereof in a method for analysing a sample of a heparin derivative. |
申请公布号 |
US2016310521(A1) |
申请公布日期 |
2016.10.27 |
申请号 |
US201615135010 |
申请日期 |
2016.04.21 |
申请人 |
SANOFI |
发明人 |
MOURIER Pierre;VISKOV Christian |
分类号 |
A61K31/727;C08B37/00 |
主分类号 |
A61K31/727 |
代理机构 |
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代理人 |
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主权项 |
1. A sulfonated polysaccharide having a polysaccharide of heparin which has a molecular weight of less than 8000 Daltons, said sulfonated polysaccharide comprising two antithrombin III-affinity sites, wherein said sulfonated polysaccharide is in mixture with other polysaccharides. |
地址 |
PARIS FR |