METHOD FOR PREPARING LIPOSOMES OF RETINALDEHYDE OR OTHER PRECURSORS OF RETINOIC ACID AND PRODUCT THUS OBTAINED

摘要

Method for preparing liposomes of retinaldehyde or another precursor of retinoic acid for obtaining liposomes that are phospholipidic in nature containing, at least partially, retinaldehyde or another precursor of retinoic acid as an active agent at a ratio of 0.01% to 1%.

主权项

1. A method for preparing liposomes of retinaldehyde or other precursors of retinoic acid characterized in that it comprises the following steps:
a mixture is prepared by solubilizing an active agent, retinaldehyde or any precursor of retinoic acid in a compatible solvent along with lipids; a derivative of cholic acid or polyoxyethylene 20 sorbitan monolaurate is added to the mixture; a product is obtained by adding the mixture to an aqueous phase, distilled water or saline in reaction equipment and homogenizing for 30 minutes at a temperature below 35° C. and under vacuum; the product is filtered through a filter of 0.2 microns.