摘要 |
The invention provides a grafted antibody, or functional fragment thereof, comprising one or more complementarily determining regions (CDRs) having at least one amino acid substitution in one or more CDRs of a heavy chain CDR, where the grafted antibody or functional fragment thereof has specific binding activity for a cryptic collagen epitope. The invention also provides methods of using an antibody having specific binding activity for a cryptic collagen epitope, including methods of inhibiting angiogenesis, tumor growth, and metastasis. |
申请人 |
CELL-MATRIX, INC.;WATKINS, JEFFRY, D.;HUSE, WILLIAM, D.;TANG, YING;BROEK, DANIEL;BROOKS, PETER C. |
发明人 |
WATKINS, JEFFRY, D.;HUSE, WILLIAM, D.;TANG, YING;BROEK, DANIEL;BROOKS, PETER C. |