DIAGNOSTIC METHODS FOR DETERMINING PROGNOSIS OF NON-SMALL CELL LUNG CANCER

摘要

The present disclosure provides methods for identifying early stage non-small-cell lung cancer (NSCLC) patients who will have an unfavorable prognosis for the recurrence of lung cancer after surgical resection. The methods are based in part on the discovery of chromosomal copy number abnormalities that can be used for prognostic classification. The methods preferably use fluorescence in situ hybridization with fluorescently labeled nucleic acid probes to hybridize to patient samples to quantify the chromosomal copy number of these genetic loci.

主权项

1. A method of predicting disease outcome in a patient being treated for lung cancer, the method comprising the steps of:
(a) providing a test sample from a patient; (b) determining a copy number of a cancer outcome marker in the test sample; (c) comparing the copy number of the cancer outcome marker in the test sample against a baseline copy number of two, thereby determining the presence or absence of a copy number change for the cancer outcome marker in the test sample; and (d) based on the presence or absence of a copy number change for the cancer outcome marker in the test sample, identifying the patient as having an increased risk of a poor disease outcome when compared to a baseline measure of disease outcome in patients having no copy number change in the cancer outcome marker, wherein the presence of a copy number change in the cancer outcome marker is predictive of poor disease outcome.