Composition comprising an array which further comprises chimeric compositions

摘要

This invention provides novel compositions and processes for analyte detection, quantification and amplification. Nucleic acid arrays and libraries of analytes are usefully incorporated into such compositions and processes. Universal detection elements, signaling entities and the like are employed to detect and if necessary or desirable, to quantify analytes. Amplification of target analytes are also provided by the compositions and processes of this invention.

主权项

1. A composition of matter that comprises an array of solid surfaces comprising a plurality of discrete areas,
wherein the plurality of discrete areas comprises a first discrete area and a second discrete area, said first discrete area and said second discrete area each comprising: a chimeric composition consisting of:
(i) a nucleic acid portion covalently attached to(ii) a peptide portion, wherein
said nucleic acid portion of the chimeric composition of said first discrete area has a different sequence from that of said nucleic acid portion of the chimeric composition of said second discrete area,said peptide portion of the chimeric composition of said first discrete area has a binding affinity for a first non-nucleic acid analyte of interest,said peptide portion of the chimeric composition of said second discrete area has a binding affinity for a second non-nucleic acid analyte,said first non-nucleic acid analyte is different from said second non-nucleic acid analyte, andsaid nucleic acid portion of the chimeric composition consists essentially of DNA, a DNA analog, PNA, or combinations thereof, wherein said covalently attached peptide portion of the chimeric composition of said first discrete area is different from said covalently attached peptide portion of the chimeric composition of said second discrete area.