| 发明名称 | Cytomegalovirus vaccines and methods of production | ||
| 摘要 | Methods of increasing diversity in cytomegalovirus vaccines through the selection of cell type in which the virus is propagated, and the use of cytomegalovirus produced by those methods in the development of vaccine compositions, are disclosed. Vaccine compositions comprising CMV isolated from epithelial cells are also disclosed. | ||
| 申请公布号 | US9439960(B2) | 申请公布日期 | 2016.09.13 |
| 申请号 | US200812681504 | 申请日期 | 2008.10.01 |
| 申请人 | The Trustees of Princeton University | 发明人 | Shenk Thomas;Wang Dai |
| 分类号 | A61K39/245;A61K39/12;A61K39/00 | 主分类号 | A61K39/245 |
| 代理机构 | Hamilton, Brook, Smith & Reynolds, P.C. | 代理人 | Hamilton, Brook, Smith & Reynolds, P.C. |
| 主权项 | 1. A method of making an immunogenic composition comprising a population of live attenuated, inactivated or killed cytomegaloviruses (CMVs), or virion components thereof, comprising: a) passaging two or more strains or isolates of CMV having a gene encoding a functional pUL131 protein in a fibroblast, b) amplifying the two or more strains or isolates of CMV in an epithelial cell, thereby producing cell type-conditioned CMVs; and c) producing a population of live attenuated, inactivated, or killed CMVs from the cell type-conditioned CMVs, thereby producing the immunogenic composition. | ||
| 地址 | Princeton NJ US | ||