FILTER FOR PORTABLE PERITONEAL DIALYSATE REGENERATION SYSTEM USING ENZYME-INCLUDED SILK FIBROIN AND METHOD FOR MANUFACTURING SAME

摘要

The present invention relates to a method for manufacturing a filter for a peritoneal dialysate regeneration system, using silk fibroin or silk protein and, more specifically, to a filter comprising silk fibroin or silk protein including an enzyme such as urease therein and to a method for manufacturing a filter for a portable peritoneal dialysate regeneration system. Silk fibroin, unlike the other polymers, does not induce an immune response in vivo, and was approved to be safe by FDA, and thus silk fibroin has been used for other medical materials including a suture thread. The filter according to the present invention can regenerate a peritoneal dialysate very effectively by effectively removing low-molecular materials. In addition, the filter of the present invention can be used simultaneously with an existing activated carbon filter, thereby allowing more effective regeneration of dialysate. The silk fibroin filter according to the present invention has advantages of mass productivity, regulatory degradability, and enzyme immobility, and thus has an excellent dialysate regeneration effect as a filter for a portable peritoneal dialysate regeneration system, in which an enzyme such as urease is immobilized.