OPTIMIZED PNE-BASED CHIMERIC RECEPTOR T CELL SWITCHES AND USES THEREOF
摘要
Disclosed herein are chimeric antigen receptor effector cells (CAR-ECs) and CAR-EC switches. The switchable CAR-ECs are generally T cells. The one or more chimeric antigen receptors may recognize a peptidic antigen on the CAR-EC switch. The CAR-ECs and switches may be used for the treatment of a condition in a subject in need thereof.
申请公布号
WO2016168773(A2)
申请公布日期
2016.10.20
申请号
WO2016US27997
申请日期
2016.04.15
申请人
THE CALIFORNIA INSTITUTE FOR BIOMEDICAL RESEARCH
发明人
YOUNG, Travis;RODGERS, David T.;HARDY, Ian;KIM, Chanhyuk;SCHULTZ, Peter G.;HAMPTON, Eric;LABORDA, Eduardo;PRESTA, Leonard