Substituted xanthine derivatives

摘要

This invention relates to novel compounds that are substituted xanthine derivatives and pharmaceutically acceptable salts thereof. For example, this invention relates to novel substituted xanthine derivatives that are derivatives of pentoxifylline. This invention also provides compositions comprising one or more compounds of this invention and a carrier and the use of the disclosed compounds and compositions in methods of treating diseases and conditions for which pentoxifylline and related compounds are beneficial.

主权项

1. A compound of Formula B: or a pharmaceutically acceptable salt thereof, wherein:
each of R1 and R2 is independently selected from —CH3 and —CD3;R5 is hydrogen or deuterium;each Z3 is hydrogen or deuterium;each Z4 is hydrogen or deuterium;each Z5 is hydrogen or deuterium;either (a) Y1 is OH, and Y2 is hydrogen or deuterium, or (b) Y1 and Y2 are taken together with the carbon to which they are attached to form C═O; andthe deuterium incorporation at each designated deuterium atom is at least 90%.