Process for the preparation of vilazodone hydrochloride and its amorphous form

摘要

The present invention relates to an improved process for the preparation of vilazodone hydrochloride and a process for preparation of novel pure amorphous form of vilazodone hydrochloride.

主权项

1. A process for preparation of a thermodynamically stable and substantially pure amorphous form of Vilazodone hydrochloride, which comprises:
a) providing a solution of Vilazodone hydrochloride in a first solvent or mixture of solvents, wherein the solvent is formic acid; b) optionally, filtering said solvent solution to remove any extraneous matter; and c) substantially removing said solvent from the solution to afford amorphous form of Vilazodone hydrochloride.