| 主权项 |
1. A compound of Formula (II):or a stereoisomer, a tautomer, or a pharmaceutically acceptable salt thereof, wherein:
R1 is independently selected from the group consisting of: C1-6 alkyl substituted with 0-2 Ra, —(CH2)2N(C1-4 alkyl)(—CH═CHCF3), and —(CH2)n—W—R1a; W is independently selected from the group consisting of: a bond, NH, N(C1-4 alkyl), CO, CONH, CON(C1-4 alkyl), SO2, NHCO2, and CHRf; R1a is independently selected from the group consisting of: C3-6 cycloalkyl substituted with 0-2 Rc, phenyl substituted with 0-2 Rb, naphthyl substituted with 0-2 Rb, dihydroindenyl substituted with 0-2 Rc, and a 5- to 6-membered heterocycle comprising: carbon atoms and 1-4 heteroatoms selected from N, NRe, O, and S(O)p; and wherein said heterocycle is substituted with 0-2 Rc; R5 is independently selected from the group consisting of: C5-6 cycloalkyl, phenyl, thienyl, pyrazolyl, imidazolyl, thiazolyl, tetrahydropyranyl, piperidinyl, pyridyl, and benzothiazolyl; and wherein each moiety is substituted with 0-2 Rd; L is X1—Y—X2; X1 is independently selected from the group consisting of: a bond, —CH═CH—, O, NH, —CH2O—, —CO—, —SO2—; X2 is independently selected from the group consisting of: —CH2—, —(CH2)2—, —(CH2)3—, —(CH2)4—, —CH(C1-4 alkyl)-, —O(CH2)2—, and —O(CH2)3—; Y is independently selected from the group consisting of: C3-6 cycloalkylene, C4-6 cycloalkenylene, phenylene, pyridylene, piperidinylene, oxadiazolylene, alternatively, R5-L- is Ra is, independently at each occurrence, selected from the group consisting of: halogen, CF3, CF2CF3, OCH2CF3, NH(C1-4 alkyl), CONH2, CONH(C1-4 alkyl), NHSO2(C1-4 alkyl), and N(C1-4 alkyl)SO2(C1-4 alkyl); Rb is, independently at each occurrence, selected from the group consisting of: halogen, C1-4 alkyl, CF3, OCF3, CONH2, and CONH(C1-4 alkyl); Rc is, independently at each occurrence, selected from the group consisting of: ═O and Rb; Rd is, independently at each occurrence, selected from the group consisting of: halogen, OH, C1-4 alkyl, C1-4 alkoxy, CF3, OCF3, CN, NH2, NH(C1-4 alkyl), N(C1-4 alkyl)2, CO(C1-4 alkyl), CO2(C1-4 alkyl), NHCO(C1-4 alkyl), —CH2NHCO(C1-4 alkyl), CONH2, CONH(C1-4 alkyl), CON(C1-4 alkyl)2, SO2(C1-4 alkyl), SO2NH2, —SO2NH(C1-4 alkyl), —SO2NH(C3-6 cycloalkyl), —NHSO2(C1-4 alkyl), —CH2NHSO2(C1-4 alkyl), and Si(C1-4 alkyl)3; Re is, independently at each occurrence, selected from the group consisting of: H, C1-4 alkyl, CO2(C1-4 alkyl), CO2(benzyl), phenyl, and benzyl; Rf is, independently at each occurrence, selected from the group consisting of: C1-4 alkyl, CO2(C1-4 alkyl), and CONH2; n is, independently at each occurrence, selected from 0, 1, 2, and 3; and p is, independently at each occurrence, selected from 0, 1, and 2; wherein said 5- to 10-membered heterocycle is each independently selected from the group consisting of pyridinyl, furanyl, thienyl, pyrrolyl, pyrazolyl, pyrazinyl, piperazinyl, piperidinyl, imidazolyl, imidazolidinyl, indolyl, tetrazolyl, isoxazolyl, morpholinyl, oxazolyl, oxadiazolyl, oxazolidinyl, tetrahydrofuranyl, thiadiazinyl, thiadiazolyl, thiazolyl, triazinyl, triazolyl, benzimidazolyl, 1H-indazolyl, benzofuranyl, benzothiofuranyl, benztetrazolyl, benzotriazolyl, benzisoxazolyl, benzoxazolyl, oxindolyl, benzoxazolinyl, benzthiazolyl, benzisothiazolyl, isatinoyl, isoquinolinyl, octahydroisoquinolinyl, tetrahydroisoquinolinyl, tetrahydroquinolinyl, isoxazolopyridinyl, quinazolinyl, quinolinyl, isothiazolopyridinyl, thiazolopyridinyl, oxazolopyridinyl, imidazolopyridinyl, and pyrazolopyridinyl. |
