Method of Treatment of Alopecia with Monoterpenoids

摘要

The present application generally relates to topical formulations comprising monoterpenoid compounds which are effective inhibitors of FGF-5-dependent signalling in hair follicles or parts thereof, the manufacture of such topical formulations, and their use to reduce, delay or prevent loss of terminal hair caused by FGF-5 signalling in the hair follicle, such as in subjects suffering from, or having a propensity to develop, alopecia

主权项

1. A topical formulation comprising an isolated C10-monoterpenoid or isolated enantiomer thereof or an isolated ester thereof with a carboxylic acid, wherein said topical formulation is formulated to extend an anagen phase of a hair follicle cell comprising a hair and/or to delay a hair follicle cell comprising a hair from entering a catagen phase in a subject to which the formulation is applied by reducing or inhibiting fibroblast growth factor 5 (FGF5)-dependent signalling in the hair follicle cell, and wherein the C10-monoterpenoid is of formula (I): wherein:
R1 is hydrogen, hydroxyl or oxygen;R2 is absent or hydrogen or hydroxyl;R3 is CH3;X is CH3 or CH2OH, orX is CH2CH2 or CHOHCH2 and X and Y together form a single bond within a 6-membered ring;Y is CH2 when X is CH3 or CH2OH, orY is CH or COH when X is CH2CH2 or CHOHCH2; andZ is a saturated or unsaturated C2—C5 alkyl or alkyl ester.