| 发明名称 |
TNF-ALPHA CONVERTING ENZYME |
| 摘要 |
A metalloprotease that converts TNF- alpha from the 26kD cell form to the cell form to the 17 kD form has been isolated and purified and the cDNA sequence known. In particular, the protease has a molecular weight of approximately 80 kD. The isolated and purified protease is useful for designing an inhibitor thereof, and may find use as a therapeutic agent. Assays for detecting the protease-inhibiting activity of a molecule are also an aspect of the invention. |
| 申请公布号 |
EP0830130(A1) |
申请公布日期 |
1998.03.25 |
| 申请号 |
EP19960923209 |
申请日期 |
1996.06.03 |
| 申请人 |
IMMUNEX CORPORATION |
发明人 |
BLACK, ROY, A.;RAUCH, CHARLES;MARCH, CARL, J.;CERRETTI, DOUGLAS, P. |
| 分类号 |
C12N15/09;A61K31/00;A61K38/00;A61K45/00;A61P9/10;A61P15/00;A61P29/00;A61P31/18;A61P37/00;A61P37/08;A61P43/00;C07K14/525;C07K16/40;C12N1/11;C12N1/13;C12N1/15;C12N5/10;C12N9/64;C12N15/57;C12N15/63;C12P21/08;C12Q1/37;(IPC1-7):A61K31/00 |
主分类号 |
C12N15/09 |
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