发明名称 |
Test for the detection of anti-heparin antibodies |
摘要 |
This invention pertains to a method of detecting, in a sample obtained from an individual, anti-heparin antibodies which inhibit the formation of the heparin accelerated antithrombin III-thrombin complex. In the present method, the presence of such anti-heparin antibodies are detected directly (by detecting the presence of anti-heparin antibodies themselves) or indirectly (by detecting the presence or formation of the heparin accelerated antithrombin III-thrombin complex). In one embodiment of the present method, antibodies which react with or interfere with the heparin pentasaccharide which binds antithrombin III in such a manner that binding to antithrombin III is inhibited are detected. In a specific embodiment of the present method, the anti-heparin antibody detected is one which reacts with or interferes with the disaccharide UA-2S/GlcNs-6 present in residues IV and V of the heparin pentasaccharide that binds antithrombin III.
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申请公布号 |
US5753445(A) |
申请公布日期 |
1998.05.19 |
申请号 |
US19940233390 |
申请日期 |
1994.04.26 |
申请人 |
THE MOUNT SINAI MEDICAL CENTER OF THE CITY UNIVERSITY OF NEW YORK |
发明人 |
FILLIT, HOWARD M.;HARPEL, PETER C. |
分类号 |
G01N33/86;(IPC1-7):G01N33/53 |
主分类号 |
G01N33/86 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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