Synthesis of substituted salicylaldehyde derivatives

摘要

Among other things, the present invention encompasses methods of synthesizing salicylaldehyde derivatives comprising the steps of: a) providing salicylaldehyde or a derivative thereof, b) forming an anhydro dimer of the provided salicylaldehyde compound, c) performing one or more chemical transformations on the anhydro dimer and d) hydrolyzing the anhydro dimer to provide a salicylaldehyde derivative different from that provided in step (a).

主权项

1. A compound of any one of formulae D14 to D18: wherein, R26 is selected from the group consisting of: hydrogen, halogen, optionally substituted C1-20 aliphatic, and optionally substituted aryl; Ra and Rb are, independently at each occurrence, selected from the group consisting of hydrogen, halogen, and optionally substituted C1-4 aliphatic; Q′ is selected from the group consisting of: halogen, hydroxyl, sulfonate ester, a neutral or cationic nitrogen-containing functional group, and a neutral or cationic phosphorous-containing functional group; and m is from 1 to 10.