CORNEAL CROSSLINKING WITH OXYGENATION

摘要

In corneal crosslinking by applying a photoactivated crosslinking facilitator such as riboflavin to the cornea and irradiating the cornea with light, the cornea is contacted with a liquid (33) containing a source of oxygen during irradiation. The liquid transfers oxygen to the cornea to facilitate crosslinking.

主权项

1. A method of crosslinking collagen in the cornea of an eye of a mammalian subject comprising the steps of:
(a) contacting a cornea of an eye of the subject with a photoactivated crosslinking facilitator, and irradiating the cornea with light at a wavelength that activates the crosslinking facilitator; and (b) during the irradiating step, contacting the cornea with a liquid including a source of oxygen.