Novel lipids and compositions for the delivery of therapeutics

摘要

H:/grs/Intrwovn/NRPortbl/DCC/GRS/I0777599_I.docx- 16/08/2016 NOVEL LIPIDS AND COMPOSITIONS FOR THE DELIVERY OF THERAPEUTICS The present invention provides lipids that are advantageously used in lipid particles for the in vivo delivery of therapeutic agents to cells. In particular, the invention provides lipids having the following structures: (Formula (I) or (XXXV)) R3 R2 (R) R3 R2 (XXXV) R3- A2 n 3X R