| 摘要 |
The present invention provides an isolated peptide having an amino acid residue sequence that comprises at least one human cytomegalovirus glycoprotein B (HCMV-gB) sequence segment, each HCMV-gB sequence segment consisting of at least 8 and not more than 60 consecutive amino acid residues from residues 146 to 315, residues 476 to 494 of SEQ ID NO: 1, or from a sequence variant of residues 146 to 315 or 476 to 494 of SEQ ID NO: 1 that has at least 70% sequence identity thereto. The peptides of the invention are useful for treating, preventing, or inhibiting a herpesvirus (e.g., Herpes Simplex Virus-1, Human Cytomegalovirus, and the like) infection in a subject. |
| 主权项 |
1. An isolated peptide consisting of residues 233 to 263 of SEQ ID NO: 1, or a sequence variant of residues 233 to 263 of SEQ ID NO: 1 that has at least 90% sequence identity thereto and that differs therefrom only by one or more conservative amino acid substitution selected from the group consisting of H234D, H234E, R236D, R236E, R243D, R243E, E244K, E244R, E244H, C245A, C245M, C250A, C250M, R258D, R258E, K260D, and K260E; and wherein the N-terminal amino group of the peptide optionally is bonded to a moiety selected from the group consisting of an acetyl group, a hydrophobic group, a carbobenzoxyl group, a dansyl group, and a t-butyloxycarbonyl group, and the C-terminal carboxyl group of the peptide optionally is bonded to a moiety selected from the group consisting of an amine and a hydrophobic group. |
