Long noncoding RNAS and cell reprogramming and differentiation

摘要

Long noncoding RNAs (lncRNAs) are identified that enhance pluripotency reprogramming of somatic cells as well as differentiation of pluripotent cells. Induced pluripotent stem (iPS) cell generation from somatic cells leads to the upregulation and downregulation of identified lncRNAs. The modulation of these lncRNAs are capable of enhancing pluripotency of somatic cells as well as enhancing differentiation of a pluripotent cell.

主权项

1. A method of enhancing reprogramming of a somatic cell to a pluripotent cell in a human or mouse, comprising:
upregulating in the somatic cell at least one long noncoding RNA (lncRNA) selected from SEQ ID NOs. 43, 272, 304, 334, 345, 395, and homologs thereof having at least 85% homology to the at least one lncRNA, the upregulating comprising adding or activating the at least one lncRNA.