发明名称 |
Polysaccharide-protein conjugates |
摘要 |
Vi capsular polysaccharides conjugated to toxin-dependent proteins can be used to enhance antibody response and to convert T-dependent properties to the Vi capsular polysaccharide. A heterobifunctional crosslinking agent can be used to bind thiol derivatives of the Vi capsular polysaccharides to the proteins, such as diphtheria, tetanus toxoids, cholera toxin and Haemophilus influenzae.
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申请公布号 |
US5204098(A) |
申请公布日期 |
1993.04.20 |
申请号 |
US19880155799 |
申请日期 |
1988.02.16 |
申请人 |
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES |
发明人 |
SZU, SHOUSUN C.;SCHNEERSON, RACHEL;ROBBINS, JOHN B. |
分类号 |
A61K39/05;A61K39/02;A61K39/08;A61K39/106;A61K39/112;A61K39/145;A61K39/385;A61K39/39;A61K39/395;A61K47/48;C07K17/10 |
主分类号 |
A61K39/05 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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