| 摘要 |
PURPOSE:To obtain a low toxic carcinostatic auxiliary having activity to significantly improve the efficacy of existing carcinostatics, containing a specific ribofuranose derivative as an active ingredient. CONSTITUTION:This auxiliary contains, as active ingredient, a ribofuranose derivative of the formula [R is a 1-6C (branches) alkyl] (e.g. 5-deoxy-5- methylthio-D-ribose, 5-deoxy-5-ethylthio-D-ribose, 5-deoxy-5-n-propylthio-D-ribose). The carcinostatic to be used in combination with this auxiliary or by containing in a formulation together with this auxiliary includes an anthracycline compound such as adriamycin, a platinum compound such as cis-diaminodichloroplatinum (II) or a fluoropyrimidine compound such as 5-fluorouracil. |
