PERSULFATED CHONDROITIN SULFATES, PROCESS FOR PRODUCING THE SAME, AND ANTICOAGULANTS CONTAINING THE SAME AS THE ACTIVE INGREDIENT

摘要

Novel compounds different from heparin and having a high anticoagulant activity. These compounds are persulfated chondroitin sulfates having at least 3.5, on average, O-sulfate groups per disaccharide repeating unit or pharmacologically acceptable salts thereof. These compounds can be produced by reacting a chondroitin sulfate salt with sulfur trioxide in an aprotic solvent at 30 to 50 DEG C by regulating the molar ratio of the free hydroxyl groups in the chondroitin sulfate salt to the sulfur trioxide of 1:10 to 1:20.