| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide compositions and methods for treating or preventing antibody mediated graft rejection. <P>SOLUTION: The invention is based in part on the discovery that blood group epitopes can be specifically expressed at high density and by different core sugar chains on mucin-type protein backbones. The polypeptides are referred to herein as ABO fusion polypeptides. In one aspect, the invention provides a fusion polypeptide that includes a first polypeptide, comprising at least a region of a mucin polypeptide, and glycosylated by an α1,2 fucosyltransferase operably linked to a second polypeptide. The first polypeptide is sequentially glycosylated by an α1,3 N-acetylgalactosaminyl transferase and/or an α1,3 galactosyltransferase. The mucin polypeptide is for example PSGL-1. <P>COPYRIGHT: (C)2009,JPO&INPIT |
