| 摘要 |
The present invention relates to a pharmaceutical composition for preventing or treating eye surface diseases, the composition containing, as an active ingredient, peptide GQDGLAGPK on the basis of collagen type II α1, isolated from the chondrocyte-derived extracellular matrix. In an alkali burn animal model treated with the peptide GQDGLAGPK, the corneal opacity was reduced and the expression of CD31 and VEGF, which are angiogenesis factors, was reduced. In addition, macrophages, TNFα, ICAM-1, VCAM-1, and MMP-9, which are inflammation markers, were reduced, and the expression of NF-κB, which is an inflammation-inducing factor, was reduced. Therefore, the peptide GQDGLAGPK of the present invention can be used as a pharmaceutical composition for preventing or treating corneal diseases, which are eye surface diseases. |
