发明名称 AURONE DERIVATIVE-CONTAINING COMPOSITION FOR DIAGNOSIS
摘要 A composition for the diagnosis of diseases relating to amyloid which con tains either a compound represented by the general formula (I): [wherein X r epresents O, etc.; R1, R3, R4, R5, R6, R8, and R9 each represents hydrogen, etc.; R2 represents halogeno, etc.; and R7 represents dimethylamino, etc.] o r a compound obtained by labeling that compound with a radionuclide or conta ins a pharmaceutically acceptable salt of any of these compounds. The compou nd represented by the general formula (I) has high bonding specificity for a myloid ß-protein, is apt to highly pass through the blood-brain barrier, and has the property of rapidly disappearing from the areas excluding senile pl aques in the brain.
申请公布号 CA2671596(A1) 申请公布日期 2008.12.06
申请号 CA20072671596 申请日期 2007.10.26
申请人 NAGASAKI UNIVERSITY 发明人 ONO, MASAHIRO
分类号 A61K51/00;C07D307/83 主分类号 A61K51/00
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