Systems and methods for generating and using projector curve sets for universal calibration for noninvasive blood glucose and other measurements

摘要

A synthetic projection system determines analyte concentration, such as blood glucose concentration, from a spectral-energy change associated with an uncharacterized instance of a medium in which the analyte is likely present. The projection system is factory calibrated for different instances of the medium, without needing instance-specific training or calibration. The projection system includes a set of projector curves, each relating spectral-energy change values obtained by analyzing reference medium samples to analyte concentrations in those samples. Each projector curve also corresponds to a respective range of energy-change gradients, determined using a group of surrogate media characterized according to analyte concentrations measured using a reference system. A spectral-energy-change gradient for the uncharacterized medium may be computed to select one of the projectors curves. Analyte concentration in the uncharacterized medium can be reliably computed at a specified high level of accuracy using the spectral-energy change associated therewith and the selected curve.

主权项

1. A method for calibrating a measurement system for non-invasive analyte measurement, the method comprising the steps of:
obtaining in memory in communication with a processor, from a selected plurality of synthetic medium samples, each having a reference analyte concentration, a plurality of energy-value sets from the measurement system, each energy value in a particular energy-value set corresponding to a respective reference analyte concentration from the selected plurality of synthetic medium samples; generating by the processor a composite projector curve using the plurality of energy value sets and the plurality of reference analyte concentrations; and partitioning by the processor the composite projector curve into a set of non-overlapping individual projector curves according to a set of slopes of the composite projector curve, each individual projector curve being identified by a lower bound analyte concentration and an upper bound analyte concentration.