PROCESS FOR PRODUCING (3R,5S)-(E)-7-[2-CYCLOPROPYL-4-(4-FLUOROPHENYL)-QUINOLIN-3-YL]-3,5-DIHYDROXYHEPT-6-ENIC ACID ESTERS

摘要

A process for producing a compound represented by the following general formula (IV): (IV) wherein R represents hydrogen, alkyl or aryl; characterized by reducing a compound selected from the group consisting of compounds represented by the following general formula (I): (I) wherein R is as defined above; compounds represented by the following general formula (II): (II) wherein R is as defined above; and compounds represented by the following general formula (III): (III) wherein R is as defined above; by treating optionally processed cells of a microorganism capable of stereoselectively reducing a keto group.