| 摘要 |
<p><P>PROBLEM TO BE SOLVED: To provide an efficient, inexpensive and stereoselective method for producing an intermediate (2S,4S)-2-[[(3R)-pyrrolidin-3-yl-(R)-hydroxy]methyl]pyrrolidine-4-thiol dihydrochloride useful for producing a new carbapenem and to provide the new intermediate thereof. <P>SOLUTION: The method for producing the intermediate from a (2S,4R)-4-alkylsilyloxy-N-t-butoxycarbonylpyrrolidine-2-carbaldehyde derivative through a new crystallizable intermediate (2S,4R)-N-t-butoxycarbonyl-2-[[(3R)-N-t-butoxycarbonylpyrrolidin-3-yl-(R)-hydroxy]methyl]-4-hydroxypyrrolidine by an aldol reaction using an asymmetric assistant such as an amino-alcohol. <P>COPYRIGHT: (C)2005,JPO&NCIPI</p> |
