发明名称 |
CYTOTOXIC MOLECULES RESPONSIVE TO INTRACELLULAR LIGANDS FOR SELECTIVE T CELL MEDIATED KILLING |
摘要 |
Compositions and methods are provided for the cell-mediated targeted killing of diseased cells based on the presence of an intracellular antigen, rather than a surface-bound marker. The targeting cells are modified to express a cytotoxic protein that is delivered into a targeted cell, and after delivery is selectively activated by the presence of a cytoplasmic protein of interest. In one embodiment of the invention, the cytotoxic molecule is a Granzyme B (GrB) polypeptide. In the compositions of the invention, GrB is modified to render its cytotoxic enzymatic functions inactive, until the presence of an intracellular antigen unlocks the GrB molecule to enable enzymatic activities. |
申请公布号 |
WO2016100233(A1) |
申请公布日期 |
2016.06.23 |
申请号 |
WO2015US65623 |
申请日期 |
2015.12.14 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
CHEN, YVONNE Y.;HO, PATRICK |
分类号 |
C12N9/50;A61K35/17;C07K14/47;C07K16/26;C07K19/00;C12N5/0783;C12N9/12;C12N9/99;C12N15/62;C12N15/86 |
主分类号 |
C12N9/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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