Polysaccharide matrix having a grafted polymer, method for producing the same and use thereof

摘要

A porous, non-particulate, convectively permeable polysaccharide matrix has a surface on which there is fixed a grafted-on polymer derived from at least one ethylenic monomer compound having functional groups, wherein the polysaccharide matrix is prepared by grafting a porous, non-particulate, convectively permeable polysaccharide starting matrix with the at least one ethylenic monomer compound in the presence of an organic acid having at least one carboxylic acid group and/or at least one acidic XH group, where X=—O, —S, or —N, and of a transition metal or lanthanide compound. The polysaccharide matrix has a high protein binding capacity. A process for preparing the polysaccharide matrix and a method for using the polysaccharide matrix for material separation also are provided.

主权项

1. A porous polysaccharide matrix comprising:
a starting matrix selected from the group consisting of a polysaccharide matrix and a porous support having a polysaccharide matrix coating; and grafted onto the starting matrix, a transition metal or lanthanide compound and an ethylenic monomer compound having functional groups; wherein the ethylenic monomer compound was grafted onto the starting matrix in the presence of an organic acid having at least one carboxylic acid group and at least one acidic X—H group, where X=O, S, or N; wherein the porous polysaccharide matrix has a static protein binding capacity that is 1.5 to 8.4 times a static protein binding capacity of a comparative matrix that was prepared by grafting in the absence of the organic acid having at least one carboxylic acid group and at least one acidic X—H group, where X=O, S, or N.