发明名称 |
Manganese ion coated nanoparticles for delivery of compositions into the central nervous system by nasal insufflation |
摘要 |
The compositions and methods of the disclosure particularly target the divalent metal transporter expressed on olfactory nerve terminals to transport divalent cation-coated or cation-containing nanoparticles to all regions of brain. It has been found that such divalent cation-containing nanoparticles, including those nanoparticles comprising manganese have affinity for the metal transport receptor proteins. Although this receptor has particular affinity for manganese, it is contemplated that other divalent ions, including magnesium, calcium, and the like may also be bound to such receptors leading to transport of the nanoparticles into the intracellular cytoplasm. Nanoparticles have been developed, therefore, as vehicles for parenteral delivery of genes, proteins and drugs. The present disclosure encompasses embodiments of nanoparticle-based compositions and methods for the use thereof for the delivery of genes, oligonucleotides, including but not limited to small interfering RNA, and other small molecule drugs, into the brain by nasal insufflation. |
申请公布号 |
US9375400(B2) |
申请公布日期 |
2016.06.28 |
申请号 |
US201214343534 |
申请日期 |
2012.09.14 |
申请人 |
University of South Florida |
发明人 |
Sanchez-Ramos Juan;Sava Vasyl;Song Shijie;Mohapatra Shyam S.;Mohapatra Subhra |
分类号 |
A61K9/00;A61K31/7088;A61K47/48;A61K9/51;A61K9/16;A61K9/50;A61K49/18;C12N15/88;C12N15/89;A61K31/713;A61K48/00 |
主分类号 |
A61K9/00 |
代理机构 |
Thomas | Horstemeyer, LLP |
代理人 |
Thomas | Horstemeyer, LLP |
主权项 |
1. A nanoparticle delivery vehicle, comprising:
a core comprising a plurality of cross-linked chitosan molecules or cross-linked thiolated chitosan molecules; and a plurality of manganese ions bonded to said cross-linked chitosan molecules or thiolated chitosan molecules. |
地址 |
Tampa FL US |