| 发明名称 | Anti-HER2 antibodies and immunoconjugates | ||
| 摘要 | The invention provides anti-HER2 antibodies and immunoconjugates and methods of using the same. | ||
| 申请公布号 | US9518118(B2) | 申请公布日期 | 2016.12.13 |
| 申请号 | US201514851001 | 申请日期 | 2015.09.11 |
| 申请人 | Genentech, Inc. | 发明人 | Chen Xiaocheng;Dennis Mark;Junutula Jagath Reddy;Phillips Gail Lewis;Pillow Thomas Harden;Sliwkowski Mark X. |
| 分类号 | C07K16/28;A61K47/48;C07K16/32;A61K39/395;G01N33/574 | 主分类号 | C07K16/28 |
| 代理机构 | McNeill Baur PLLC | 代理人 | McNeill Baur PLLC |
| 主权项 | 1. An isolated antibody that binds to HER2, wherein the antibody comprises (a) HVR-H1 comprising the amino acid sequence of SEQ ID NO:15; (b) HVR-H2 comprising the amino acid sequence of SEQ ID NO:16; (c) HVR-H3 comprising the amino acid sequence of SEQ ID NO:17; (d) HVR-L1 comprising the amino acid sequence of SEQ ID NO:12; (e) HVR-L2 comprising the amino acid sequence of SEQ ID NO:13; and (f) HVR-L3 comprising the amino acid sequence of SEQ ID NO:14. | ||
| 地址 | South San Francisco CA US | ||