主权项 |
1. A method for treating cancer, the method comprising:
administering to a patient in need of treatment an effective amount of a purified (+) enantiomer compound substantially free of a corresponding (−) enantiomer, the (+) enantiomer compound having the formula (FX2): wherein: ring A is X is —OH, —OCH3, or C2-C8 alkoxy; Y is —H or —OH; W is —(CR10R11)—, —(C═O)—, —(C═S)—, —(C═CR12R13)—, or —(CR14NR15R16—); each of R1 and R2 is independently —H, —CH3, —(O−), C1-C10 alkyl, C3-C10 cycloalkyl, C2-C10 alkenyl, C1-C10 haloalkyl, C5-C10 aryl, C5-C10 heteroaryl, C5-C10 alkylaryl, C5-C10 alkylheteroaryl, C5-C10 carbonylalkenylaryl, or C5-C10 carbonylalkenylheteroaryl; each of R3-R16 and R50-R54 is independently —H, —OH, —OCH3, C1-C8 alkyl, C3-C8 cycloalkyl, C2-C8 alkenyl, C2-C8 alkoxy, C5-C10 aryl, C5-C10 heteroaryl, C5-C10 alkylaryl, C5-C10 alkylheteroaryl, halo, nitrile, C1-C8 haloalkyl, C1-C10 hydroxyalkyl, or C5-C10 carbonylalkenylheteroaryl; and when n is 1, and the nitrogen to which R2 is attached has a positive charge and optionally is associated with an anion. |